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<blockquote>It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal epithelial cell barrier, and tissue remodeling all contribute to the chronic inflammatory and tissue-deforming processes characteristic of CRS. [https://www.ncbi.nlm.nih.gov/pubmed/26654193]</blockquote>
 
<blockquote>It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal epithelial cell barrier, and tissue remodeling all contribute to the chronic inflammatory and tissue-deforming processes characteristic of CRS. [https://www.ncbi.nlm.nih.gov/pubmed/26654193]</blockquote>
  
<blockquote>Complex microbial communities have co-evolved with our species. At any one time, an individual can host 10 to 100 trillion microorganisms, outnumbering human cells by at least a factor of 10. Bacterial communities have been demonstrated on the mucosa of the entire respiratory tract, with the highest concentrations being found in the upper respiratory tract... There is some recent evidence that mucosal inflammation in the paranasal sinuses is associated with a decreased diversity of the local bacterial communities. Particular microbial species known as “keystone species” may have an exceptionally large impact on the ecosystem's function and health. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251963/]</blockquote>
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<blockquote>Complex microbial communities have co-evolved with our species. At any one time, an individual can host 10 to 100 trillion microorganisms, outnumbering human cells by at least a factor of 10. Bacterial communities have been demonstrated on the mucosa of the entire respiratory tract, with the highest concentrations being found in the upper respiratory tract. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251963/]</blockquote>
  
 
===Biofilms===
 
===Biofilms===

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