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Pharmaceutical remedies claim to offer intermediate relief for severity between herbal and surgical remedies. Some are systematic (affecting the entire body), while others are local (applied directly to the nose and upper respiratory tract). Topical drugs in the affected areas have fewer side effects. Pharmaceuticals often have serious side effects, and some drugs are only available with a prescription. Drugs often only work for a few hours at a time, and for a few days in a row, making them problematic for chronic rhinosinusitis.
 
Pharmaceutical remedies claim to offer intermediate relief for severity between herbal and surgical remedies. Some are systematic (affecting the entire body), while others are local (applied directly to the nose and upper respiratory tract). Topical drugs in the affected areas have fewer side effects. Pharmaceuticals often have serious side effects, and some drugs are only available with a prescription. Drugs often only work for a few hours at a time, and for a few days in a row, making them problematic for chronic rhinosinusitis.
  
* [[Non-steroidal anti-inflammatories]] (NSAIDs) include aspirin, ibuprofen, naproxen, and others. These reduce inflammation throughout the entire body. These are inexpensive and widely available, although they do have severe side effects [https://www.ncbi.nlm.nih.gov/pubmed/16531187] and as such are not ideal for extended use.
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* [[Non-steroidal anti-inflammatories]] (NSAIDs) include aspirin, ibuprofen, naproxen, and others. These reduce inflammation throughout the entire body. These are inexpensive and widely available, although they do have side effects and as such are not ideal for extended use.
 
* [[Steroids]] can be applied topically or ingested. These require a few days, weeks, or months to take effect, although unlike most pharmaceuticals can be taken for extended use. They work by reducing inflammation and encouraging blood flow in the affected area. Spray steroids are now available without a prescription, and do not carry the same side effects as the systemic steroids that some athletes take, although still are not recommended for children. Steroids have some side effects, although they do not have rebound effect like most sinus sprays.
 
* [[Steroids]] can be applied topically or ingested. These require a few days, weeks, or months to take effect, although unlike most pharmaceuticals can be taken for extended use. They work by reducing inflammation and encouraging blood flow in the affected area. Spray steroids are now available without a prescription, and do not carry the same side effects as the systemic steroids that some athletes take, although still are not recommended for children. Steroids have some side effects, although they do not have rebound effect like most sinus sprays.
 
** All varieties of steroid spray are equivalently effective. [https://www.ncbi.nlm.nih.gov/books/NBK279484/]
 
** All varieties of steroid spray are equivalently effective. [https://www.ncbi.nlm.nih.gov/books/NBK279484/]

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