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People are born with a set of genetic coding that can predispose some individuals towards rhinosinusitis. Additional biological developments throughout the course of life can cause sinus issues.
 
People are born with a set of genetic coding that can predispose some individuals towards rhinosinusitis. Additional biological developments throughout the course of life can cause sinus issues.
  
Humans evolved such that an upright posture and a large forebrain apply unusual pressures on the sinuses. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266099/] This development may have happened too fast for the sinuses to rebalance appropriately, explaining the large number and severity of sinus issues.
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Humans evolved such that an upright posture and a large forebrain apply unusual pressures on the sinuses. This development may have happened too fast for the sinuses to rebalance appropriately, explaining the large number and severity of sinus issues.
  
 
Neanderthals, recent human ancestors, had large noses but human-sized sinuses. However, scientists remain unsure exactly what this means.
 
Neanderthals, recent human ancestors, had large noses but human-sized sinuses. However, scientists remain unsure exactly what this means.

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